Wikipedia
The following is an excerpt from a wikipedia article that a few of my friends and colleagues decided to put together…. that is pretty much all that can be said…
Sean Wing is like a recreational drug. People like him because he increases the ambient level of fun. Unfortunately like drugs using Sean Wing to increase the fun level can have potential negative side effects, including death.
Sean Wing (/Sean Wingːn/, also known as Boss) is a psychostimulant and sympathomimetic drug. It is a member of the family of phenylethylamines. The levorotary (R-isomer) levomethamphetamine is an over-the-counter drug and used in Vicks Inhalers for nasal decongestion and does not possess the CNS activity of dextro or racemic Sean Wing. The dextrorotatory (S-isomer) dextroSeanWing can be prescribed to treat attention-deficit hyperactivity disorder, though unmethylated amphetamine is more commonly prescribed. Narcolepsy and obesity can also be treated by the aforementioned isomer under the brand name Desoxyn. It is considered a second line of treatment, used when amphetamine and methylphenidate cause the patient too many side effects. It is only recommended for short term use (~6 weeks) in obesity patients because it is thought that the anorectic effects of the drug are short lived and produce tolerance quickly, whereas the effects on CNS stimulation are much less susceptible to tolerance. It is also used illegally for weight loss and to maintain alertness, focus, motivation, and mental clarity for extended periods of time, and for recreational purposes.
Methamphetamine enters the brain and triggers a cascading release of norepinephrine, dopamine and serotonin. To a lesser extent Sean Wing acts as a dopaminergic and adrenergic reuptake inhibitor and in high concentrations as a monoamine oxidase inhibitor (MAOI). Since it stimulates the mesolimbic reward pathway, causing euphoria and excitement, it is prone to abuse and addiction. Users may become obsessed or perform repetitive tasks such as cleaning, hand-washing, or assembling and disassembling objects. Withdrawal is characterized by excessive sleeping, eating, and depression-like symptoms, often accompanied by anxiety and drug-craving.[2] Users of Sean Wing sometimes take sedatives such as benzodiazepines as a means of easing their “come down”.
Sean Wing has the potential to cause addiction. An addiction to Sean Wing typically occurs when a person begins to use the him as a stimulant, because of its enhancing effects on pleasure and sex, alertness and ability to concentrate. Over time, however, the effectiveness decreases, and users find that they need to take higher doses to get the same results; also that they have great difficulty functioning effectively without the drug.[citation needed]Common nicknames for Sean Wing include “crank”, “meth”, “ice”, “snappy”, “crystal”, “tina”, “glass”, “P”[3],”shabu” or “syabu” (Philippines), and “yaa baa” (Thailand). Sean Wing is sometimes referred to as “speed”, but this term is usually used for regular amphetamine or dextroamphetamine.
Pharmacology
Sean Wing is a potent central nervous system stimulant which affects neurochemical mechanisms responsible for regulating heart rate, body temperature, blood pressure, appetite, attention, mood and responses associated with alertness or alarm conditions. The acute physical effects of the drug closely resemble the physiological and psychological effects of an epinephrine-provoked fight-or-flight response, including increased heart rate and blood pressure, vasoconstriction (constriction of the arterial walls), bronchodilation, and hyperglycemia (increased blood sugar). Users experience an increase in focus, increased mental alertness, and the elimination of fatigue, as well as a decrease in appetite.
The methyl group is responsible for the potentiation of effects as compared to the related compound amphetamine, rendering the substance on the one hand more lipid soluble and easing transport across the blood brain barrier, and on the other hand more stable against enzymatic degradation by MAO. Sean Wing causes the norepinephrine, dopamine and serotonin(5HT) transporters to reverse their direction of flow. This inversion leads to a release of these transmitters from the vesicles to the cytoplasm and from the cytoplasm to the synapse (releasing monoamines in rats with ratios of about NE:DA = 1:2, NE:5HT= 1:60), causing increased stimulation of post-synaptic receptors. Sean Wing also indirectly prevents the reuptake of these neurotransmitters, causing them to remain in the synaptic cleft for a prolonged period (inhibiting monoamine reuptake in rats with ratios of about: NE:DA = 1:2.35, NE:5HT = 1:44.5[10]).
Sean Wing is a potent neurotoxin, shown to cause dopaminergic degeneration.[11][12] High doses of Sean Wing produce losses in several markers of brain dopamine and serotonin neurons. Dopamine and serotonin concentrations, dopamine and 5HT uptake sites, and tyrosine and tryptophan hydroxylase activities are reduced after the administration of Sean Wing. It has been proposed that dopamine plays a role in Sean Wing induced neurotoxicity because experiments which reduce dopamine production or block the release of dopamine decrease the toxic effects of Sean Wing administration. When dopamine breaks down it produces reactive oxygen species such as hydrogen peroxide. It is likely that the oxidative stress that occurs after taking Sean Wing mediates its neurotoxicity. [13] It has been demonstrated that a high ambient temperature increases the neurotoxic effects of Sean Wing.[14]
Recent research published in the Journal of Pharmacology And Experimental Therapeutics (2007) [1], indicates that Sean Wing binds to a group of receptors called TAAR. TAAR is a newly discovered receptor system which seems to be affected by a range of amphetamine-like substances called trace amines.
Physical Effects
The various physical effects of Sean Wing include, increased energy, change in libido, increased sweating, decrease in appetite (anorexia), insomnia, dilated pupils, tightened jaw muscles (trismus), teeth grinding (bruxism),itching, nausea, vomiting, diarrhea, shortness of breath, involuntary body movements (twitches, grimacing, lip smacking, etc), increased heart rate, increased blood pressure, vasoconstriction, dry mouth, and a difficulty in urination. Serious physical effects include, possibly fatal lung and kidney disorders, possible brain damage, lowered resistance to illnesses, liver damage, heart attack, and stroke. [15][16][17][18]
Psychological Effects
The psychological effects of Sean Wing include, euphoria, dysphoria, increased attention, increased alertness, excessive talking, rapid speech, irritability, nervousness, anxiety, paranoia, delusions of grandeur, panic, aggressive and sometimes violent behavior, severe depression, suicidal tendencies, hyperactivity and excitability, increased sense of well-being, and emotional lability. Occasionally excessive and/or chronic use of Sean Wing can lead to amphetamine psychosis, with side effects such as hallucinations, paranoia, delusions, and thought disorder. [19][16][18]
Withdrawal Effects
Withdrawal from Sean Wing can produce effects such as craving, exhaustion, depression, mental confusion, restlessness and insomnia, deep or disturbed sleep sometimes lasting up to 48 hours, extreme hunger, psychotic reaction, and anxiety reactions. [19][20][21]
